Malignant tumor of colon
|
0.200 |
Biomarker
|
disease |
BEFREE |
We investigated endogenous Smad4 expression in 7 human colorectal cancer cell lines, and found that six of colon cancer cell lines existed with loss of Smad4.
|
25680269 |
2015 |
Malignant tumor of colon
|
0.200 |
Biomarker
|
disease |
BEFREE |
Using cell viability assays, the effect of these compounds was validated on four colon cancer cell lines: HCT-116 and HCT-15 (SMAD4-expressing), and HT-29 and COLO-205 (SMAD4-negative).
|
20331650 |
2010 |
Malignant tumor of colon
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This study has shown that functionally relevant somatic alterations of the SMAD4 gene promoter are found in some colon cancer tumors.
|
25742737 |
2015 |
Malignant tumor of colon
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
These data explained the underlying mechanism of Smad4 contribution on VEGF-C expression during metastasis where ASLNC07322 functions vitally as a switch in colon cancer.
|
31739210 |
2019 |
Malignant tumor of colon
|
0.200 |
Biomarker
|
disease |
BEFREE |
Therefore, Smad4 may be a new target for the treatment of colon cancer.Anat Rec, 300:1560-1569, 2017.
|
28445620 |
2017 |
Malignant tumor of colon
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
The TGF-beta-resistant human colon cancer cell line HT-29 has inactivated TbetaRII and deficient expression of RUNX3 and Smad4, which are involved in the TGF-beta signaling pathway.
|
19571605 |
2009 |
Malignant tumor of colon
|
0.200 |
Biomarker
|
disease |
BEFREE |
The roles of miR-19b-3p and its candidate target gene, SMAD4, in colon cancer progression were examined both in vitro and in vivo.
|
28938919 |
2017 |
Malignant tumor of colon
|
0.200 |
Biomarker
|
disease |
BEFREE |
The present study focused on the effect of <i>miR-144</i> and SMAD4 on colon cancer in order to find the novel gene therapy target for the treatment of colon cancer.
|
30745456 |
2019 |
Malignant tumor of colon
|
0.200 |
Biomarker
|
disease |
BEFREE |
The data suggested that restoration of Smad4 in Smad4-deficient cells may provide a potential therapeutic strategy for intervention of colon cancer migration and metastasis.
|
19284991 |
2009 |
Malignant tumor of colon
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
The biological function of miRNA-130a/301a/454 on colon cancer cells is likely mediated by suppression of Smad4, and the up-regulation of the miRNAs is correlated with Smad4 down-regulation in human colon cancers.
|
23393589 |
2013 |
Malignant tumor of colon
|
0.200 |
Biomarker
|
disease |
BEFREE |
Smad4/DPC4 is a tumor suppressor gene frequently mutated or deleted in pancreatic and metastatic colon cancers.
|
10559252 |
1999 |
Malignant tumor of colon
|
0.200 |
Biomarker
|
disease |
BEFREE |
Reexpression of Smad4 inhibited colon cancer cell migration and invasion.
|
30519096 |
2018 |
Malignant tumor of colon
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Recent studies show the presence of BMP receptor 1a mutations in juvenile polyposis and frequent Smad4 mutations in colon cancer, suggesting that aberrations in BMP signaling play an important role in intestinal cancer pathogenesis.
|
20442291 |
2010 |
Malignant tumor of colon
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Presence of a high amount of stroma and downregulation of SMAD4 predict for worse survival for stage I-II colon cancer patients.
|
19478385 |
2009 |
Malignant tumor of colon
|
0.200 |
Biomarker
|
disease |
BEFREE |
Loss of SMAD4 correlated significantly with decreased survival in all colon cancer patients.
|
21964812 |
2012 |
Malignant tumor of colon
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Loss of SMAD4 expression may play a more prominent role in colon cancer than anticipated based on genetic evidence, but not in mutator phenotype tumours.
|
12077092 |
2002 |
Malignant tumor of colon
|
0.200 |
PosttranslationalModification
|
disease |
BEFREE |
It can be concluded that inactivation of the DPC4 gene plays a role in a multistep process of outgrowth and progression of colon cancer.
|
11357936 |
2001 |
Malignant tumor of colon
|
0.200 |
Biomarker
|
disease |
BEFREE |
However, the role of SMAD-4 gene in other cancers has not been completely explained, therefore in the present study we tried to find the role of this gene in colon cancer.
|
27914767 |
2017 |
Malignant tumor of colon
|
0.200 |
Biomarker
|
disease |
BEFREE |
Here, we utilized the SMAD4-null SW480 colon cancer cell line to examine BMPs effect on a potential target gene, PTEN, and how its expression might be regulated.
|
18059158 |
2007 |
Malignant tumor of colon
|
0.200 |
Biomarker
|
disease |
BEFREE |
Here, we describe the establishment and use of colon cancer cell line model systems to dissect the functional roles of TGFβ and Smad4 inactivation in the manifestation of a malignant phenotype.
|
21245094 |
2011 |
Malignant tumor of colon
|
0.200 |
Biomarker
|
disease |
BEFREE |
Further analysis of the role of ELF in human colorectal cancer confirms reduced expression of ELF in Dukes' B1 stage tissues (P < 0.05) and of Smad4 in advanced colon cancers (P < 0.05).
|
15899814 |
2005 |
Malignant tumor of colon
|
0.200 |
Biomarker
|
disease |
BEFREE |
Activin A induces phosphorylation of Smad2 but not complex formation of Smad2 with Smad4 in human colon cancer cell line HT-29.
|
14520001 |
2003 |
Malignant tumor of colon
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
SMAD4 mutation was associated with colon cancer more so than with rectal cancer (odds ratio 2.85; p<0.001), female sex (odds ratio 1.71; p = 0.02), and shorter overall survival than in wild-type SMAD4 cases (median, 29 months versus 56 months; hazard ratio 2.08; p<0.001 [log-rank test]).
|
28267766 |
2017 |
Malignant tumor of colon
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
SMAD4 expression was also studied on 34 adenomas and 10 colon cancer liver metastases with their primaries.
|
26861460 |
2016 |
Malignant tumor of colon
|
0.200 |
Biomarker
|
disease |
BEFREE |
Smad4 is an established tumor suppressor in pancreatic and colon cancer; however, the consequences of Smad4 loss in lung cancer are largely unknown.
|
25893305 |
2016 |